Welcome! I am an associate professor in the Department of Mathematics at Ohio State University. My research primarily concerns infectious disease dynamics. Specific research interests include disease dynamics on networks, cholera dynamics, and understanding how factors at the level of the individual affect population level disease dynamics.

- Jacobsen KA, Tien JH. A generalized inverse for graphs with absorption.
*Submitted.*Arxiv preprint. - Jacobsen KA, Burch MG, Tien JH, Rempala GA. The large graph limit of a stochastic epidemic model on a dynamic multilayer network.
*Submitted.*Arxiv preprint. - Lee EC, Kelly MR, Ochocki BM, Akinwumi SM, Hamre KES, Tien JH, Eisenberg MC. Model distinguishability and inference robustness in mechanisms of cholera transmission and loss of immunity.
*Submitted.*Arxiv preprint.### Published

- Burch MG, Jacobsen KA, Tien JH, Rempala GA. Network-based analysis of a small Ebola outbreak.
*Mathematical Biosciences and Engineering.*Accepted. - Lin C-J, Deger KA, Tien JH. 2016. Modeling the trade-off between transmissibility and contact in infectious disease dynamics.
*Mathematical Biosciences.*277: 15-24. - Kelly MR, Tien JH, Eisenberg MC, Lenhart S. 2016. The impact of spatial arrangements on epidemic disease dynamics and intervention strategies.
*Journal of Biological Dynamics.*10(1): 222-249. - Tien JH, Shuai Z, Eisenberg MC, van den Driessche P. 2015. Disease invasion on community networks with environmental pathogen movement.
*Journal of Mathematical Biology.*70(5): 1065-1092. - Healy-Profitos JM, Mouhaman A, Lee S, Garabed R, Moritz M, Piperata B, Tien J, Bisesi M, Lee J. 2014. Muddying the waters: a new area of concern for drinking water contamination in Cameroon.
*International Journal of Environmental Research and Public Health.*11(12): 12454-12472. - Devault AM, Golding GB, Waglechner N, Enk JM, Kuch M, Tien JH, Shi M, Fisman DN, Dhody AN, Forrest S, Bos KI, Earn DJD, Holmes EC, Poinar HN. 2014. Second-pandemic strain of
*Vibrio cholerae*from the Philadelphia cholera outbreak of 1849.*New England Journal of Medicine.*doi: 10.1056/NEJMoa1308663. - Eisenberg MC, Kujbida G, Tuite AR, Fisman DN, Tien JH. 2013. Examining rainfall and cholera dynamics in Haiti using statistical and dynamic modeling approaches.
*Epidemics.*5: 197-207. - Robertson SL, Eisenberg MC, Tien JH. 2013. Heterogeneity in multiple transmission pathways: modeling the spread of cholera and other waterborne disease in networks with a common water source.
*Journal of Biological Dynamics.*7(1): 254-275. - Eisenberg MC, Shuai Z, Tien JH, van den Driessche P. 2013. A cholera model in a patchy environment with water and human movement.
*Mathematical Biosciences.*246(1): 105-112. doi: 10.1016/j.mbs.2013.08.003. - Eisenberg MC, Robertson SL, Tien JH. 2013. Identifiability and estimation of multiple transmission pathways in cholera and waterborne disease.
*Journal of Theoretical Biology.*324: 84-102. - Shuai Z, Tien JH, van den Driessche P. 2012. Cholera models with hyperinfectivity and temporary immunity.
*Bulletin of Mathematical Biology.*74(10): 2423-2445. doi: 10.1007/s11538-012-9759-4. - Holte S, Randolph T, Ding J, Tien JH, McClelland R, Baeten J, Overbaugh J. 2012. Efficient use of longitudinal CD4 counts and viral load measures in survival analysis.
*Statistics in Medicine.*31(19): 2086-2097. doi: 10.1002/sim.5318. - Tuite AR, Tien JH, Eisenberg MC, Earn DJD, Ma J, Fisman DN. 2011. Cholera epidemic in Haiti, 2010 - using a transmission model to explain spatial spread of disease and identify optimal control interventions.
*Annals of Internal Medicine.*154(9): 593-601. - Tien JH, Poinar HN, Fisman DN, Earn DJD. 2011. Herald waves of cholera in 19th century London.
*Journal of the Royal Society Interface*8(58): 756-760. doi:10.1098/rsif.2010.0494. - Lyles D, Tien JH, McCobb DP, Zeeman ML. 2010. Pituitary network connectivity as a mechanism for the LH surge.
*Journal of Neuroendocrinology*22(12): 1267-1278. - Tien JH, Earn DJD. 2010. Multiple transmission pathways and disease dynamics in a waterborne pathogen model.
*Bulletin of Mathematical Biology*72(6): 1506-1533. - Tien JH, Guckenheimer J. 2008. Parameter estimation for bursting neural models.
*Journal of Computational Neuroscience*24(3): 358-373. - Guckenheimer J, Tien JH. 2007. Commentary on "Parameter estimation for differential equations: a generalized smoothing approach" by Ramsay JO, Hooker G, Campbell D, Cao J.
*Journal of the Royal Statistical Society B*69(5): 741-770. - Guckenheimer J, Tien JH, Willms AR. 2005. Bifurcations in the fast dynamics of neurons: implications for bursting. In:
*Bursting: the genesis of rhythm in the nervous system.*(Eds.) Coombes S, Bresloff PC. World Scientific Press, pp. 91-124. - Tien JH, Hazelton WD, Sparks R, Ulrich CM. 2005. A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase.
*Bulletin of Mathematical Biology*67: 683-700. - Tien JH, Lyles D, Zeeman ML. 2005. A potential role of modulating inositol 1,4,5-trisphosphate receptor desensitization and recovery rates in regulating ovulation.
*Journal of Theoretical Biology*232(1): 105-117. - Hazelton WD, Tien JH, Donato VW, Sparks R, Ulrich CM. 2004. Prostaglandin H syntases: members of a class of quasi-linear threshold switches.
*Biochemical Pharmacology*68(3): 423-432. - Tien JH, Levin SA, Rubenstein DI. 2004. Dynamics of fish shoals: identifying key decision rules.
*Evolutionary Ecology Research*6: 555-565.

I am teaching a course on the mathematics of infectious disease dynamics in Spring 2016. If you are interested in learning about modeling infectious disease dynamics, for example for use in your own research or future employment, please check out the class!

Some courses I have taught previously are listed below:

- Fall 2015: Dynamical systems (Math 4556).
- Spring 2014: Calculus I (Math 1151).
- Spring 2013: Mathematical modeling for the life sciences (Math 1157).
- Autumn 2012: Mathematical topics for engineers (Math 2177).
- Winter 2012, Spring 2011: Ordinary and partial differential equations (Math 415).
- Fall 2010: Topics in mathematical ecology (co-taught with Yuan Lou, Libby Marschall, Ian Hamilton).
- Spring 2009: Differential equations III (Math 617).
- Winter 2009: Introduction to real analysis (Math 547).

**Post-docs** interested in working with me are encouraged to apply for the three year postdoctoral fellowships at the Mathematical Biosciences Institute (MBI) here at Ohio State.

Interested **graduate students** can apply to either the math department's Ph.D. program or the Master's program in mathematical biology. An overview of all graduate programs in the department can be found here.

I also work with students in the Epidemiology Division of the College of Public Health. I currently have an opening for an MPH or PhD student in public health, to work on a cholera risk assessment project. This project can potentially form the basis for either an MPH culminating project, or part of a PhD thesis. This project is part of a NSF grant on modeling cholera dynamics.

**Undergraduates** at OSU can study mathematical biology through the biology track within the mathematics major. For several years, OSU was home to the RUMBA program, which provided opportunities to pursue research in mathematical biology. MBI also holds an annual summer program on mathematical biology for undergraduates. This latter program is open to undergraduates outside of Ohio State as well.

Current and former students and postdocs I have worked with are listed here.